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Fatigue is a condition in which a person becomes weary or exhausted. It is usually caused by overdoing some physical activity. It can also occur after a long period of mental stress. In some cases, it may occur for no clear reason.

The causes of fatigue include:
- stress
- lack of sleep or difficulty sleeping
- infections, such as acute bronchitis, mononucleosis and AIDS
- a low blood count
- working, studying or exercising too much
- lack of exercise or poor physical conditioning
- hormone imbalances, such as hypothyroidism
- chronic fatigue syndrome
- depression or other psychological disorders, including emotional conflict, anxiety, frustration and boredom
- autoimmune disorders
- toxin or chemical exposure
- allergies
- medications
- heart disease or disorders
- lung diseases and disorders
- kidney disorders
- liver disease
- digestive disorders
- uncontrolled diabetes
- cancer

The symptoms are:
- Fever
- Pain
- Nausea
- Vomiting
- Diarrhea
- Blood in urine or stool
- Shortness of breath
- Chest pain
- Constipation
- Muscle cramps or aches
- Easy bruising
- Cough
- Changes in thirst or urination
- Inability to sleep lying flat
- Inability to walk up more than one flight of stairs
- Changes in appetite
- Loss or gain of weight
- Menstrual irregularities
- Swollen legs

Tests for fatigue include :
- Blood tests
- Urinalysis
- Chem-7
- Thyroid function tests
- Pregnancy test
- Sed rate
- HIV test
- Chest x-ray
- ECG
- CT scan of head